Korean J Asthma Allergy Clin Immunol.  2011 Dec;31(4):304-306.

A Case of Acute Generalized Exanthematous Pustulosis Induced by Sodium Salicylate

Abstract

BACKGROUND
Acute generalized exanthematous pustulosis (AGEP) is a rare disease mostly related to drug eruption. The skin lesions present as widespread sterile pustules on erythematous bases, usually accompanied by fever and leukocytosis. CASE HISTORY: A 62 year old woman presented with generalized multiple tiny pustules and erythematous confluent patches on the trunk and proximal extremities. Two weeks ago, a sodium salicylate agent was injected at a local clinic to subside chilling sensation. The skin lesion appeared 10 days after the injection and was accompanied by a high fever.
RESULTS
Laboratory tests revealed leukocytosis and elevated erythrocyte sedimentation rate. The histopathological examination of the skin biopsy specimen showed subcorneal spongiform pustules with perivascular inflammatory cell infiltration. The patient was diagnosed with AGEP and treated with systemic steroids and antihistamines. The lesion resolved after 3 weeks.
CONCLUSION
Herein, we report a rare case of AGEP induced by sodium salicylate injection.

MeSH Terms

Acute Generalized Exanthematous Pustulosis
Biopsy
Blood Sedimentation
Drug Eruptions
Extremities
Female
Fever
Histamine Antagonists
Humans
Leukocytosis
Rare Diseases
Sensation
Skin
Sodium
Sodium Salicylate
Steroids
Histamine Antagonists
Sodium
Sodium Salicylate
Steroids