Korean J Asthma Allergy Clin Immunol.
2011 Dec;31(4):246-251.
Gut Microflora, Lifestyles and Allergic Diseases: The Epidemiological Evidence
Abstract
- The current evidence supports a role of gut colonization in promoting and maintaining a balanced immune response during early life. Increasingly, epidemiologic and clinical data support the hypothesis that perturbation in the gastrointestinal microflora due to antibiotic use and dietary differences in 'industrialized' countries disrupt normal microflora-mediated immunological tolerance in the mucosa, leading to an increase in the prevalence of allergic diseases. However, there has not been fully adequate longitudinal study of the relation between the infant gut microflora, the development of allergic diseases and the changes of lifestyles. The consensus of opinion is currently still lacking. However, a complex interplay among a host's immune response, characteristics of the gut microflora, a genetic background and the range of exposures become apparent. Even if at this time, practical implications cannot be deduced directly from these findings, there is a high potential for the development of novel preventive and therapeutic strategies in the future based on the concept of the microflora hypothesis.
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