Korean J Anesthesiol.  2008 Aug;55(2):176-181. 10.4097/kjae.2008.55.2.176.

The effects of continuous infusion of ondansetron on postoperative nausea and vomiting in patients receiving IV-patient controlled analgesia following gynecological surgery

• Lim SM
• Kim JY
• Kang H
• Baek CW
• Park JW
• Jung YH
• Woo YC
• Koo GH
• Park SG

• KMID: 2299200
• DOI: http://doi.org/10.4097/kjae.2008.55.2.176

Abstract

BACKGROUND
This study was designed to evaluate the effects of continuous infusion of ondansetron on postoperative nausea and vomiting (PONV) in patients receiving intravenous patient controlled analgesia (IV-PCA) following laparoscopic gynecological surgery.
METHODS
Sixty ASA class I and II patients scheduled for gynecological laparoscopic surgery were randomly divided into the following 3 groups that received the specified dosages of ondansetron mixed with IV-PCA: placebo (group 1), ondansetron 8 mg (group 2), ondansetron 16 mg (group 3). The incidences of nausea, vomiting, visual analogue scale (VAS), and side effects were then recorded in the recovery room, 24 h, 48 h and 72 h postoperatively.
RESULTS
There were no significant differences in the occurrence of nausea between group 1 and 2. However, the incidence of nausea in group 3 was significantly lower than in group 1 at 24 h and 48 h after surgery. In addition, significant differences in the occurrence of vomiting were observed among the three groups. However, with the exception of pruritus, no side effects were observed in any of the groups.
CONCLUSIONS
IV-PCA mixed with 16 mg of ondansetron effectively prevented nausea at 24 h and 48 h after gynecologic laparoscopic surgery.

Keyword

alfentanil; IV-PCA; ondansetron; PONV

MeSH Terms

Alfentanil
Analgesia
Analgesia, Patient-Controlled
Female
Gynecologic Surgical Procedures
Humans
Incidence
Laparoscopy
Nausea
Ondansetron
Postoperative Nausea and Vomiting
Pruritus
Recovery Room
Vomiting
Alfentanil
Ondansetron