Korean J Anesthesiol.  2001 Jul;41(1):33-38. 10.4097/kjae.2001.41.1.33.

The Effect of Timing of Ondansetron Administration on Nausea and Vomiting during Intravenous Patient-Controlled Analgesia

• Kim DH
• Cho DH
• Park CH

• KMID: 2298987
• DOI: http://doi.org/10.4097/kjae.2001.41.1.33

Abstract

BACKGROUND: This study was designed to establish the optimal timing of administration of ondansetron for prevention of postoperative nausea and vomiting (PONV) during intravenous patient-controlled analgesia (IV-PCA).
METHODS
Eighty women undergoing a total abdominal hysterectomy under general anesthesia were randomized to receive a placebo (n = 20, group 1), ondansetron 2 mg before induction and 2 mg after surgery (n = 20, group 2), ondansetron 4 mg before induction (n = 20, group 3), or ondansetron 4 mg after surgery (n = 20, group 4). An IV-PCA using butorphanol and ketorolac was connected to the patients after waking from the anesthesia. The incidences and severity of nausea and vomiting were recorded for 48 hr postop.
RESULTS
The incidences of nausea and vomiting in group 1 (75%, 40%) were significantly decreased after ondansetron administration but there were no significant differences among the ondansetron groups (group 2; 45%, 20%, group 3; 45%, 15%, group 4; 40%, 10%) (P < 0.05).
CONCLUSIONS
The prophylactic administration of ondansetron is effective in preventing PONV during IV-PCA, but the timing of ondansetron administration has no effect on its efficacy.

Keyword

Analgesia: patient-controlled; Pharmacology: ondansetron; Vomiting: nausea; postoperative

MeSH Terms

Analgesia, Patient-Controlled*
Anesthesia
Anesthesia, General
Butorphanol
Female
Humans
Hysterectomy
Incidence
Ketorolac
Nausea*
Ondansetron*
Postoperative Nausea and Vomiting
Vomiting*
Butorphanol
Ketorolac
Ondansetron