Korean J Aerosp Environ Med.  2000 Sep;10(3):235-240.

A Study on the Effects of Taking the Drink Containing Benzoic Acid on Analysis of Hippuric Acid in Urine

Affiliations
  • 1Aeromedical Center in ROKAF.
  • 2Department of Pharmacology, School of Medicine, Kangwon National University.

Abstract

BACKGROUND: Benzoic acid contained in some food can hinder the biological monitoring of hippuric acid in urine, which is frequently used as an exposure index of toluene and xylene. METHOD: 20 male examinees who are not exposed to organic solvents in their jobs were given a bottle of drink containing benzoic acid(70 mg/dl) and took it. Urine samples were taken from every person just before, in 1.5 hrs after, and in 3 hrs after taking the drink. Hippuric acid in urine was analyzed with improved Ogata and Taguchi method and creatinine with Jaffe method. RESULT: Mean hippuric acid concentrations in urine just before, in 1.5 hrs after, and in 3 hrs after taking the drink were 0.59+/-0.21 g/g creatinine, 2.75+/-0.98 g/g creatinine, 1.04+/-0.58 g/g creatinine, respectively. And, each group had statistically significant differences (p<0.01). There were no statistically significant differences between two groups categorized by age, smoking, and drinking.
CONCLUSION
From the results, we suggest that when hippuric acid concentration in urine is used as a exposure index of toluene, it should be surveyed whether the food containing benzoic acid was taken or not.

Keyword

hippuric acid; benzoic acid; urine; high performance liquid chromatography(HPLC)

MeSH Terms

Benzoic Acid*
Creatinine
Drinking
Environmental Monitoring
Humans
Male
Smoke
Smoking
Solvents
Toluene
Xylenes
Benzoic Acid
Creatinine
Smoke
Solvents
Toluene
Xylenes
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