Korean Diabetes J.  2008 Jun;32(3):215-223. 10.4093/kdj.2008.32.3.215.

The Association of Plasma HDL-Cholesterol Level with Cardiovascular Disease Related Factors in Korean Type 2 Diabetic Patients

• Hong HS
• Park JS
• Ryu HK
• Kim WY

• KMID: 2298092
• DOI: http://doi.org/10.4093/kdj.2008.32.3.215

Abstract

BACKGROUND: Cardiovascular disease (CVD) is the major cause of death in type 2 diabetic patients. The purpose of this study was to investigate the characteristics of Korean type 2 diabetes mellitus (DM) patients according to plasma high density lipoprotein (HDL) cholesterol level and to document the effect of diet on HDL-cholesterol.
METHODS
The subjects were 252 (male: 134, female: 118) Korean type 2 DM patients recruited from a general hospital's DM clinic and divided into low HDL-cholesterol group (male < 40 mg/dL, female < 50 mg/dL) and control group (male > or = 40 mg/dL, female > or = 50 mg/dL). Anthropometric and hematological variables and dietary intake were assessed by the groups.
RESULTS
The subject's mean age was 60.2 +/- 1.1 years and duration of diabetes was 9.5 +/- 1.0 years. Anthropometric measurements (body fat mass, % body fat, WHR, fat free mass, and muscle mass) and BMI were not significantly different between two groups. The male subjects with low HDL-cholesterolemia showed higher Atherogenic Index (AI, P < 0.001) and higher % carbohydrate from energy than control group (P < 0.01). The female subjects with low HDL-cholesterolemia showed higher AI (P < 0.001) and a tendency of higher triglyceride level and lower intake of energy, protein, lipid, vitamin B1 and vitamin E (P < 0.05) than control group.
CONCLUSION
The subject with low HDL-cholesterolemia showed significantly higher AI. Male subject with low HDL-cholesterolemia consumed higher carbohydrate and female subject with low HDL-cholesterolemia showed lower intakes of many nutrients. This result suggests the importance of an adequate and balanced diet to manage type 2 DM patients to prevent CVD complications.

Keyword

Cardiovascular disease; Low HDL-cholesterolemia; Nutrient intake; Type 2 diabetes mellitus

MeSH Terms

Adipose Tissue
Cardiovascular Diseases
Cause of Death
Cholesterol
Diabetes Mellitus, Type 2
Diet
Female
Humans
Lipoproteins
Male
Muscles
Plasma
Thiamine
Vitamin E
Vitamins
Cholesterol
Lipoproteins
Thiamine
Vitamin E
Vitamins

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