J Rheum Dis.  2013 Aug;20(4):231-237. 10.4078/jrd.2013.20.4.231.

Microvascular Findings in Patients with Rheumatoid Arthritis: Assessed, Using Fundus Photography and Fluorescein Angiography

• Yeo HJ
• Lee JH
• Lee HJ
• Byun KS
• Im HJ
• Kim MJ

• KMID: 2297537
• DOI: http://doi.org/10.4078/jrd.2013.20.4.231

Abstract

OBJECTIVE
Although a series of trials support that rheumatoid arthritis (RA) is associated with increased atherosclerosis, the link between microvascular structural changes and the disease activity of RA has not been clarified. We measured changes in the retinal microvasculature using fundus fluorescein angiography (FAG) and investigated the association between the retinal vasculature and clinical parameters of RA.
METHODS
Seventy-five RA patients and sixty healthy control were included. Morphometric and quantitative features in the capillary images including retinal vascular signs and vessel diameters were measured with fundus photography and FAG. RA activity was assessed based on high sensitivity C-reactive protein (hsCRP), disease activity score with 28 joints (DAS 28), and health assessment questionnaire (HAQ).
RESULTS
Central retinal arteriolar equivalents (CRAE) was 118.1+/-31.3 microm in RA patients and 123.8+/-19.9 microm in control subjects, showing the tendency of retinal arteriolar narrowing in patients with RA but without statistical significance. The mean central retinal venular equivalents (CRVE) was 162.4+/-26.4 microm which was significantly higher than that of control group (144.1+/-23.1 microm, p<0.001). The prevalence of AVN was 34.7%, and significantly higher in RA group. Among retinal findings, the presence of early pinpoint hyperfluorescence and areas of delayed choroidal perfusion correlated with hsCRP. Age, disease duration, DAS 28, HAQ, and rheumatoid factor (RF) had no effect on CRAE and CRVE. In multivariate analysis, only hsCRP was found to be associated with wider venular caliber.
CONCLUSION
Retinal venular widening was more common in RA patients. Retinal venular diameter had significant correlation with disease activity of RA. Retinal imaging is a comparative method for the assessment of microvascular findings of RA patients.

Keyword

Rheumatoid arthritis; Fundus photography; Central retinal arteriolar equivalents; Central retinal venular equivalents

MeSH Terms

Arthritis, Rheumatoid
Atherosclerosis
C-Reactive Protein
Capillaries
Choroid
Fluorescein
Fluorescein Angiography
Humans
Joints
Microvessels
Multivariate Analysis
Perfusion
Photography
Prevalence
Rheumatoid Factor
Surveys and Questionnaires
C-Reactive Protein
Fluorescein
Rheumatoid Factor

Reference

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