Allergy Asthma Immunol Res.  2016 Sep;8(5):466-470. 10.4168/aair.2016.8.5.466.

Genes Involved in Interleukin-1 Receptor Type II Activities Are Associated With Asthmatic Phenotypes

• Madore AM
• Vaillancourt VT
• Bouzigon E
• Sarnowski
• Monier F
• Dizier MH
• Demenais F
• Laprise C

• KMID: 2295157
• DOI: http://doi.org/10.4168/aair.2016.8.5.466

Abstract

PURPOSE
Interleukin-1 (IL-1) plays a key role in inflammation and immunity and its decoy receptor, IL-1R2, has been implicated in transcriptomic and genetic studies of asthma.
METHODS
Two large asthma family collections, the French-Canadian Saguenay-Lac-St-Jean (SLSJ) study and the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA), were used to investigate the association of SNPs in 10 genes that modulate IL-1R2 activities with asthma, allergic asthma, and atopy. Gene-gene interactions were also tested.
RESULTS
One SNP in BACE2 was associated with allergic asthma in the SLSJ study and replicated in the EGEA study before statistical correction for multiple testing. Additionally, two SNPs in the MMP2 gene were replicated in both studies prior to statistical correction and reached significance in the combined analysis. Moreover, three gene-gene interactions also survived statistical correction in the combined analyses (BACE1-IL1RAP in asthma and allergic asthma and IL1R1-IL1RAP in atopy).
CONCLUSIONS
Our results highlight the relevance of genes involved in the IL-1R2 activity in the context of asthma and asthma-related traits.

Keyword

Atopy; asthma; IL1R1; IL1R2; genetic; SNP×SNP

MeSH Terms

Asthma
Epidemiologic Studies
Genetics
Humans
Inflammation
Interleukin-1*
Phenotype*
Polymorphism, Single Nucleotide
Receptors, Interleukin-1 Type II*
Interleukin-1
Receptors, Interleukin-1 Type II

Figure

• 

  Figure Schema of the genes involved in IL-1R2 activities analysed in this study. This figure represents the potential actions and interactions of genes involved in the IL1R2 gene activities in the bronchus of an asthmatic individual. Arrows represent the interactions between genes selected. The upper panel shows the possible involvement of the receptor IL-1R1 in the TH1 and TH17 immune response. The bottom panel illustrates the actions of IL-1R2 in the TH2 immune response. The complete information about the genes selected are available in the Supplementary Table E4.

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