J Korean Acad Fam Med.
2006 Oct;27(10):807-814.
Association between Insulin Resistance and Metabolic Syndrome in Healthy Adults: Comparison of the NCEP-ATP III and New IDF Definition
- Affiliations
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- 1Department of Family Medicine, Inje University Seoul Paik Hospital, Korea. jamiemom@hanmail.net
- 2Inje Istitute of Advanced Studies, Inje University, Korea.
Abstract
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BACKGROUND: Currently, several definitions for metabolic syndrome are in use. For epidemiological and clinical purposes, universally accepted definition would be needed. International Diabetes Federation (IDF) has introduced a new diagnostic criteria for the metabolic syndrome (MS). We analyzed the association between insulin resistance and MS using both the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) definition and new IDF definition, in order to compare the clinical utility of these two different definitions.
METHODS
The subjects of this study included 206 men, aged 29~65 years, who visited a health promotion center located in Seoul. Among the subjects, we excluded hypertensive or diabetic patients. We measured their waist circumference, blood pressure, fasting glucose, insulin and lipid profiles. The metabolic syndrome was diagnosed using both ATP III and IDF definitions. We used the multiple logistic regression method to estimate odds ratio for MS according to the level insulin resistance measured by HOMA-IR.
RESULTS
The prevalence of metabolic syndrome was 14.1% according to the NCEP-ATP III defintion, and 12.6% according to the IDF definition. After adjusting for age, alcohol, smoking and exercise, the odds ratios for insulin resistance of metabolic syndrome group defined by NCEP-ATP III criteria and IDF criteria were 3.04 (95%CI 1.28~7.22) and 2.33 (0.95~5.76) respectively.
CONCLUSION
New IDF definition does not seem to be as sensitive as ATP III definition with respect to insulin resistance. Studies using the new IDF definition for metabolic syndrome are still scarce and therefore further investigations will be required.
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