Korean Circ J.  2004 Apr;34(4):410-414. 10.4070/kcj.2004.34.4.410.

Acute Thrombosis in Coronary and Renal Arteries after Cisplatin and 5-Fluorouracil Administration

• Park OY
• Jeong MH
• Cho S
• Shim DS
• Yang BR
• Hong YJ
• Lee SH
• Park WS
• Kim W
• Kim JH
• Ahn YK
• Cho JG
• Park JC
• Kang JC

• KMID: 2294368
• DOI: http://doi.org/10.4070/kcj.2004.34.4.410

Abstract

A 55-year old male presented with chest and abdominal pain for four hours. One day prior to admission he had received chemotherapeutic agents comprising 130 mg cisplatin and 5,200 mg 5-Fluorouracil for nasopharyngeal carcinoma. EKG showed ST elevations in the leads II, III and aVF. The levels of cardiac enzymes were elevated [creatine kinase (CK) 1129 U/L, CK-MB 180 U/L, troponin T 1.23 ng/mL and troponin I 23.29 ng/mL]. Urokinase was administered at the emergency room, but the patient's chest pain continued with persistent ST segment elevations. Urgent coronary and renal angiograms revealed thrombotic occlusive lesions in the distal right coronary and right renal arteries. Percutaneous transluminal renal angioplasty using 6.0x20 mm balloon was performed for the renal artery. However, filling defects and distal renal flow were not improved and so Abciximab (ReoPro(r)) was administered. Follow-up coronary and renal angiograms on the fifth hospital day showed no filling defects with good distal flow in both right coronary and renal arteries.

Keyword

Myocardial infarction; Platelets; Angioplasty

MeSH Terms

Abdominal Pain
Angioplasty
Chest Pain
Cisplatin*
Electrocardiography
Emergency Service, Hospital
Fluorouracil*
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction
Phosphotransferases
Renal Artery*
Thorax
Thrombosis*
Troponin I
Troponin T
Urokinase-Type Plasminogen Activator
Cisplatin
Fluorouracil
Phosphotransferases
Troponin I
Troponin T
Urokinase-Type Plasminogen Activator