Korean J Urol.
2003 Dec;44(12):1238-1242.
Changes of Urinary Prostaglandin in Female Patients with Overactive Bladder
- Affiliations
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- 1Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea. kjc@catholic.ac.kr
Abstract
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PURPOSE: Prostaglandin levels in the urinary bladder can be affected by lesions of the bladder.Also, this change can be noted in the urine. This study investigated the change in urinary prostaglandin in female patients with overactive bladder.
MATERIALS AND METHODS
The study groups included 80 female patients with overactive bladder and 15 healthy female controls. Evaluation included history taking, urinalysis, voiding diary and urodynamics. The urinary concentrations of prostaglandin E2(PGE2) and prostaglandin F2alpha(PGF2alpha) in voided urine were analyzed by enzyme linked immunosorbent assay(ELISA) and these results were compared with the control group.
RESULTS
From an analysis of the voiding history, the most common complaint was urgency. Also, the capacity for first voiding sense and maximal capacity were decreased in patients from the urodynamic study. Bladder instabilities were noted in 29 patients. The urinary concentrations of PGE2 and PGF2alpha were significantly increased in the patient group compared with the control group. PGE2 level in patients was proportional to the capacity for first voiding sense and maximal capacity. However, PGF2alpha was not correlated with clinical symptoms or measurements in urodynamic studies.
CONCLUSIONS
PGE2 and PGF2alpha may play a role in lower urinary tract symptoms, and their changes can be detected in urine sample. Therefore, changes in urinary prostaglandin level may be a useful marker to evaluate lower urinary tract symptoms.
