The Prognostic Factors Influencing the Survival Rate in Patients with Localized Renal Cell Carcinoma

Yi, Jeong Won; Kim, Young Joo; Kim, Youn Wha; Chang, Sung Goo

Abstract

PURPOSE: The prognostic factors influencing the survival rate of patients with localized renal cell carcinomas were evaluated.
MATERIALS AND METHODS
The records of 100 patients that had undergone a radical nephrectomy for renal cell carcinomas, and who were pathologically diagnosed with T1N0M0 and T2N0M0 carcinomas, between January 1990 and January 2002, were reviewed. The survival rate according to each prognostic factor, such as T1 or T2 stage, nuclear grade, histologic type, microscopic vascular invasion, the expression of p53 protein and the expression of Human Erythrocyte Glucose Transporter (Glut-1), was analyzed by the Kaplan-Meier method.
RESULTS
Among the 100 patients, metastases occurred in 11 and death in 10. The 5-year survival rates of the T1 and 2 were 84 and 89%, respectively. According to the Fuhrman grade, the 5-year survival rates for grades I, II, III and IV were 100, 87, 84 and 64%, respectively. According to the histologic type, the 5-year survival rates for the conventional type, papillary type and chromophobe type were 84, 100 and 88%, respectively. There was no significant difference in the survival rate between the groups, according to the stage, Fuhrman grade and histologic type (p>0.05). No statistical differences were noted between the two groups for microscopic vascular invasion, the expression of p53 protein and the expression of Glut-1 (p>0.05).
CONCLUSIONS
Localized renal cell carcinomas treated by a radical nephrectomy had a good prognosis (5-year survival rate: 85%). Fuhrman nuclear grade IV and microscopic vascular invasion tended to have poor prognoses.