Korean J Urol.  2001 Dec;42(12):1284-1290.

Influence of Age, Rate of Obesity, Hepatic Function and Renal Function on Serum Prostate-Specific Antigen in Men Older than 50 Years

• Ku JH
• Jeon YS
• Kim ME
• Lee NK
• Park YH
• Ahn JO

Abstract

PURPOSE: We investigated the influence of age, rate of obesity, hepatic function and renal function on serum prostate-specific antigen in healthy men older than 50 years.
MATERIALS AND METHODS
From January 1999 to December 2000, 2,296 healthy Korean men older than 50 years who visited Health Promotion Center at our hospital for a routine health checkup were entered into a prospective study. All men underwent detailed clinical examinations, including serum prostate-specific antigen (PSA) determination using Hybritech Tandem-R assay, anthropometric measurements, tests for liver disease, tests for renal function, and other constitutes. We determined the risk factors of the increase of serum PSA among these clinical parameters using univariate and multivariate logistic regression analyses.
RESULTS
The univariate logistic regression analysis indicated that age, alanine aminotransferase (ALT), hemoglobin, potassium, albumin, high-density lipoprotein (HDL) were the risk factors of the increase of serum PSA. In the multivariate model used, age, ALT, alkaline phosphatase, albumin, HDL and cholesterol were an independent predictors of the increase of serum PSA, whereas hemoglobin and potassium lost their statistical significance.
CONCLUSIONS
Our findings suggest that the health status as well as may influence on serum PSA level of healthy men older than 50 years. Additional work is needed to determine and validate the clinical significance of these findings.

Keyword

Prostate-specific antigen; Age; Health status

MeSH Terms

Alanine Transaminase
Alkaline Phosphatase
Cholesterol
Health Promotion
Humans
Lipoproteins
Liver Diseases
Logistic Models
Male
Obesity*
Potassium
Prospective Studies
Prostate-Specific Antigen*
Risk Factors
Alanine Transaminase
Alkaline Phosphatase
Cholesterol
Lipoproteins
Potassium
Prostate-Specific Antigen