J Korean Acad Child Adolesc Psychiatry.
2007 Oct;18(2):154-161.
No Association of DRD4 Exon III Polymorphism with Attention-Deficit Hyperactivity Disorder in Korean Children Population
- Affiliations
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- 1Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.
- 2Department of Psychiatry, College of Medicine, Chonbuk National University, Jeonju, Korea.
- 3Department of Neuropsychiatry, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Abstract
OBJECTIVES
The aim of the current study is to test for the association of DRD4 exon III VNTR polymorphism with attention-deficit hyperactivity disorder(ADHD) in Korean children population.
METHODS
113 Korean children with ADHD, 102 parents, and 133 control subjects participated with the current study. The distribution of genotypes and alleles of DRD4 exon III VNTR in children with ADHD was compared with that in control subjects. In addition, 69 children with ADHD and their parents were analyzed using the transmission disequilibrium test(TDT).
RESULTS
We could not find any significant differences in the distribution of genotypes and alleles at DRD4 exon III VNTR polymorphism between children with ADHD and control subjects. In addition, there was no preferential transmission of long allele of DRD4 exon III VNTR polymorphism.
CONCLUSION
These results suggest that DRD4 is not associated with ADHD in Korean children population.
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