J Korean Acad Child Adolesc Psychiatry.  2013 Sep;24(3):151-156.

D8/17 Expression on B Lymphocytes of Children and Adolescents with Tic Disorder

• Oh YG
• Park TW
• Jung YW
• Chung SK
• Chung YC
• Yang JC

Abstract

OBJECTIVES
It has been reported that higher percentage of B cells react with monoclonal D8/17 antibody in patients with rheumatic fever, childhood onset obsessive-compulsive disorder, Tourette's disorder, or prepubertal anorexia nervosa. The purpose of this study is to replicate the previous studies in a Korean young population with tic disorder and to identify any relationship between D8/17 and clinical symptoms.
METHODS
The binding of D8/17 to B cells was determined in patients with tic disorder (N=21) and healthy controls (N=9) by Fluorescence-Activated Cell Sorter analysis.
RESULTS
In the sample examined by this study, the average percentage of B cells expressing D8/17 in tic disorder was 2.05%; healthy controls was 3.15%. No statistically significant differences were found in the mean percentages of D8/17 between the two groups.
CONCLUSION
The expression of D8/17 in B cells was very low in this study. No subjects with tic disorder or healthy controls was above 12% in D8/17 positive proportion. Further studies, including higher number of patients and control group members, should be performed.

Keyword

Tic Disorder; D8/17; ASO; PANDAS; FACS

MeSH Terms

Adolescent*
Anorexia Nervosa
B-Lymphocytes*
Child*
Humans
Obsessive-Compulsive Disorder
Rheumatic Fever
Tic Disorders*
Tics*
Tourette Syndrome