Korean J Urol.  1997 Oct;38(10):1059-1062.

Bladder Mucosal Mast Cell Response in Bladder Tumor

• Ki DS
• Kim HY
• Park NJ
• Sun HS
• Kim TK

Abstract

Mast cells are immune-mediators producing cells and involved in neovascularization of some tumors. Such roast cell is divided into two cell types: mucosal mast cell and connective tissue mast cell. There are controversies about the roles of mast cells in suppression and metastasis of some tumors (including bladder tumor). We performed bladder mucosal biopsies in 28 patients (from September 1994 to July 1996) and observed bladder mucosal mast cell responses in bladder tumor (TCC) under toluidine blue stain (x 400). Patients were divided into 2 groups: group A was consisted of bladder tumor patients (21 cases), whereas group B was the control group (7 cases). Mast cell responses, average mucosal mast cell counts in high power field, in group A and B were 1.75+/-0.25 cells/HPF, 0.29+/-0.20 cel1/HPF respectively. We observed more mast cell responses in bladder tumor patients group. But fundamental researches will be needed to elucidate the causes of mast cell activation in bladder tumor.

Keyword

Mast cell; Bladder tumor

MeSH Terms

Biopsy
Connective Tissue
Humans
Mast Cells*
Neoplasm Metastasis
Tolonium Chloride
Urinary Bladder Neoplasms*
Urinary Bladder*
Tolonium Chloride