Donor Factors Influencing the Graft Survival of Kidney Transplants

Park, Cheol Geun; Lee, Jong Jin; Park, Hae Young

Abstract

PURPOSE: The purpose of our study is to analyze the graft survival rates of renal transplantation in view of kidney donors, and to determine the donor parameters influencing kidney graft survival rates.
MATERIALS AND METHODS
We have analyzed kidney graft survival rates and duration according to sex, age, relationship and HLA matching performed in Hanyang University Hospital from 1986 to 1997 in 284 cases among 408 donor-recipients over a follow-up period of 24 months.
RESULTS
Among 284 recipients, the total graft losses were 34 cases(12%). Matching for the HLA-DR significantly improved kidney graft survival rates. The difference between 0 mismatched group and 2 mismatched group was 19% at 5 years(95% vs. 76%; p<0.05). An impressive 37% difference in kidney graft survival rates was observed at 5 years between recipients who received 0 and 4 HLA-B+DR mismatches(98% vs. 61%; p<0.05). The age, sex or donor-recipient relationships did not significantly influence the graft outcome. The 5-year kidney graft survival rates in siblings was 93%, which was not significantly different from 88% in the parents-children group and 80% in the unrelated group, respectively(p>0.05). There were no significant differences in graft survival rates according to HLA-A, B, A+B and A+B+DR, respectively.
CONCLUSIONS
The age, sex and donor-recipient relationship did not influence the graft outcome, but matching for the HLA-DR and B+DR significantly influenced graft survival rates in the cyclosporine A treated primary kidney recipients.