Korean J Urol.
1997 Sep;38(9):973-978.
The Causes of Elevated Serum Prostatic Specific Antigen (PSA) Concentrations in Nonprostatic Cancer Group
- Affiliations
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- 1Department of Urology, Keimyung University School of Medicine, Taegu, Korea.
- 2Department of Pathology, Keimyung University School of Medicine, Taegu, Korea.
- 3Institude for Medical Science, Keimyung University School of Medicine, Taegu, Korea.
Abstract
- Elevations of serum PSA concentrations have been widely reported due to prostatic cancer, but other causes haute not been formally characterized or quantified. So that, we evaluated the causes of elevated serum PSA concentrations in men whose prostate biopsy showed no cancer. The effects of prostate volume, inflammation, echogenecity on ultrasound and calculi were examined in 43 men that serum PSA concentrations greater than 4.0 ng/ml with negative biopsy. These men were compared with 16 men who had suspicious rectal examinations, negative biopsy and serum PSA concentrations of 4.0 ng/ml. or less. Prostate volume (22.5%, p<0.005) and inflammation (3%, p<.05) were significantly associated with elevated serum PSA concentrations (>4.0 ng/ml) than control group (< or = 4.0 ng/ml) and age echogenecity on ultrasound and calculi were statistically less significant (p> or =0.05). In summary, prostate volume and inflammation were the most important factors contributing to increase serum PSA concentration in men that clinically undetectable prostatic cancer.
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