Korean J Urol.
1998 Oct;39(10):947-951.
The Effect of Spinal Cord Injury on Pituitary-Testicular Hormone Axis in Rats
- Affiliations
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- 1Department of Urology, Chonnam University Medical School, Kwangju, Korea.
- 2Department of Biology, Chonnam University Medical School, Kwangju, Korea.
Abstract
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PURPOSE: To investigate the effect of spinal cord injury(SCI) on male reproductive function, we evaluated changes of pituitary-testicular hormonal level at various time intervals in spinal cord injured rats.
MATERIALS AND METHODS
SCI was produced in 30 sexually mature Sprague-Dawley rats by T10 spinal cord transection. 20 controls received similar surgery without transection. Testosterone concentrations in the serum and testis, serum levels of follicle-stimulating hormone(FSH) and leutenizing hormone(LH) were measured with radioimmunoassay. Two way analysis of variance(ANOVA) was performed.
RESULTS
Testosterone levels in the serum and testis were lower at 2 weeks after injury than in controls, but others were not. Serum levels of FSH and LH were similar in both group.
CONCLUSIONS
Spinal cord injury in rats induced impairment of testosterone production in testis at 2 weeks.
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