Prognostic significance of nuclear morphometry in T1, grade II bladder tumors

Kim, Han Gwun; Lee, Eun Sik; Lee, Chongwook

Abstract

Prognostic significance of the nuclear morphometry in 60 patients with initial T1 G II bladder tumor was evaluated. Clinical informations such as tumor size. multiplicity. recurrence pattern were abstracted and nuclear morphometric values such as mean nuclear area, standard deviation of nuclear area, mitotic activity index, volume-corrected mitotic index were analyzed from initial pathologic slide using image analyzer(Amersham RAS R-1000 receptor analysis system). Univariate and multivariate analyses were performed to define the influences of clinical informations and nuclear morphometric values on progression or recurrence of the tumors. In univariate analysis, mean nuclear area greater than 90um2, volume-corrected mitotic index greater than 24 and mitotic activity index greater then 15 influenced significantly to the tumor progression as well as recurrence. The standard deviation of nuclear area greater than 18um2 influenced significantly only to the tumor progression. In multivariate analysis, the most significant prognostic factor with respect to the progression was mean nuclear area. The group of patients with mean nuclear area greater than 90um2 showed 7.82 times more likely to progress. No significant prognostic factor was identified in multivariate analysis with respect to the recurrence. Nuclear morphometry provides valuable and objective informations to predict the possibility of progression in individual T1. Grade II bladder tumor patient.