Korean J Urol.  1993 Jun;34(3):420-425.

The significance of positivity of proliferating cell nuclear antigen in transitional cell carcinoma of the bladder

• Lee JB
• Kim WH
• Lee SE

Abstract

The positivity of proliferating cell nuclear antigen (PCNA) was assessed immunohistochemicelly in 75 human transitional cell carcinomas of the bladder. 4 Normal mucosa had a mean value of 29.9+/-3.35 % cells positive for PCNA, whereas the average of tumor was 75.1+/-12.8. The positivities of PCNA were 69.0+/-15.0%, 75.5+/-13.1 % 76.7+/-11.6% for grade 1, 2, 3. respectively. The average of positivity or PCNA was slightly increased as the histopathologic grade is higher, but the difference were statistically insignificant. The positivity of PCNA according to pathologic stage was 72.1+/-15.5 % for stage Ta, 76.19+/-12.8% for stage T1 and 75.6+/-12.0% for stage equal to or higher than T2 Significant differences were not noted between stage Ta and T1, and also between stage T1 and T2 or higher. In the patients who received radical cystectomy for invasive tumors, correlation was not observed between the positivity of PCNA and survival of the patient. In conclusion, PCNA seems to be valueless as a additional prognostic factor to the current histopathologic grade and stage, and not helpful to predict the survival of the patients in transitional cell carcinoma of the bladder.

Keyword

Transitional cell carcinoma; Proliferating cell nuclear antigen

MeSH Terms

Carcinoma, Transitional Cell*
Cystectomy
Humans
Mucous Membrane
Proliferating Cell Nuclear Antigen*
Urinary Bladder*
Proliferating Cell Nuclear Antigen