Korean J Stroke.  2012 Dec;14(3):95-105.

Focused Update of Korean Clinical Practice Guidelines for the Thrombolysis in Acute Stroke Management

• Cho KH
• Ko SB
• Kim DH
• Park HK
• Cho AH
• Hong KS
• Yu KH
• Heo JH
• Kwon SU
• Bae HJ
• Oh CW
• Kwon OK
• Lee BC
• Yoon BW
• Rha JH

Abstract

Since the release of first Korean Clinical Practice Guideline of Stroke in 2009, many important new evidences have emerged in the field of thrombolytic therapy. Among the recent developments are the extended therapeutic time window of intravenous (IV) tissue plasminogen activator (tPA) up to 4.5 hours after onset, and the efforts for the wider application of IV thrombolysis to patients with minor stroke and elderly patients over 80 years old. Debates about the optimal dose of IV tPA according to the ethnic population is still ongoing. Further evidences for the efficacy of intra-arterial thrombolysis have also accumulated, including the application of various novel mechanical devices with promising results. Thus update of guideline became necessary and we revise the acute stroke management guideline, focusing on the thrombolytic therapy.

Keyword

Clinical practice guideline; Ischemic stroke; Acute treatment; Thrombolysis; Intravenous; Intra-arterial; Mechanical; Recanalization

MeSH Terms

Aged
Humans
Stroke
Thrombolytic Therapy
Tissue Plasminogen Activator
Tissue Plasminogen Activator