J Gynecol Oncol.  2009 Dec;20(4):257-259. 10.3802/jgo.2009.20.4.257.

A favorable maternal and neonatal outcome following chemotherapy with etoposide, bleomycin, and cisplatin for management of grade 3 immature teratoma of the ovary

• Ghaemmaghami F
• Abbasi F
• Abadi AG

• KMID: 2288594
• DOI: http://doi.org/10.3802/jgo.2009.20.4.257

Abstract

Ovarian cancer rarely complicates pregnancy. Usually these malignancies consist of germ cell tumors. Preserving maternal safety along with favorable neonatal outcome is a subject of debate in the management of ovarian cancer during pregnancy. In this report, the authors describe a 25-year-old primigravid woman who was diagnosed to with an ovarian immature teratoma which was diagnosed at 13th weeks of pregnancy during a routine sonography. She underwent oophorectomy at week 21 of her gestation. Then she received three cycles of BEP regimen (bleomycin, etoposide, and cisplatin) during her pregnancy until week 37 of gestation. At 36 weeks she delivered a male baby with mild glandular hypospadia who was otherwise normal. Management of immature teratoma after the first trimester of pregnancy is similar to non-pregnant patients and is safe for both the mother and the fetus.

Keyword

Germ cell tumor; Ovary; Pregnancy; Chemotherapy

MeSH Terms

Adult
Bleomycin
Cisplatin
Etoposide
Female
Fetus
Humans
Hypospadias
Male
Mothers
Neoplasms, Germ Cell and Embryonal
Ovarian Neoplasms
Ovariectomy
Ovary
Pregnancy
Pregnancy Trimester, First
Teratoma
Bleomycin
Cisplatin
Etoposide

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