Korean J Schizophr Res.  2012 Oct;15(2):99-105. 10.16946/kjsr.2012.15.2.99.

Psychomotor Performance Relevant to Driving Ability in Patients with Schizophrenia Treated with Haloperidol and Aripiprazole

Affiliations
  • 1Department of Psychiatry, Seoul National Hospital, Seoul, Korea.
  • 2Department of Mental Health Research, Seoul National Hospital, Seoul, Korea. swroh@korea.kr
  • 3Ansan Yoon Neuropsychiatric Clinic, Ansan, Korea.
  • 4Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Abstract


OBJECTIVES
This study aimed to compare psychomotor performance related with automobile driving in patients with schizophrenia under the treatment of a typical antipsychotic agent, haloperidol, or an atypical antipsychotic agent, aripiprazole.
METHODS
We evaluated driving ability of schizophrenia patients by using the cognitive perceptual assessment for driving (CPAD). Twelve patients receiving haloperidol monotherapy and 18 taking aripiprazole monotherapy participated in this study and the results of CPAD were compared with each other.
RESULTS
Of 30 participants, 15 (50%) of the patients passed the CPAD to be regarded as competent to drive, 3 (10%) of the patients failed the CPAD considered to be severely impaired. Controlling for sex, age, education, duration of illness, there were no significant differences in the CPAD results between two treatment groups. We observed a trend that patients who received aripiprazole showed a higher total score of the CPAD than haloperidol-treated patients (55.2+/-4.9 vs. 45.7+/-8.4, p=0.080).
CONCLUSION
There were no significant differences in the psychomotor performance relevant to driving ability between haloperidol and aripiprazole groups. But our results suggest that aripiprazole might have the neurocognitive advantage over haloperidol. Future study with a large sample size and diverse antipsychotics is warranted.

Keyword

Schizophrenia; Haloperidol; Aripiprazole; Driving; Psychomotor performance

MeSH Terms

Antipsychotic Agents
Automobile Driving
Haloperidol
Humans
Imidazoles
Nitro Compounds
Piperazines
Psychomotor Performance
Quinolones
Sample Size
Schizophrenia
Aripiprazole
Antipsychotic Agents
Haloperidol
Imidazoles
Nitro Compounds
Piperazines
Quinolones
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