Korean J Psychopharmacol.  2008 Jan;19(1):19-28.

Psychiatric Implications of Error-Related Negativity: Focused on Symptom Severity and Medication Response

• Kim EY
• Lee SH

Abstract

Error-related negativity (ERN) is a wave, called a component that occurs in an EEG recording when a person detects an error. More specifically, ERN is an average response that follows repeated stimuli that are interpreted by a person as incorrect. The typical protocol contrasts trials on which there are errors with trials without errors, and compares the average response of both types of trials. This paper describes factors that affect the magnitude of ERN introducing current research in which ERN has been studied in psychiatric patients including autism, schizophrenia, and obsessive-compulsive disorder. The purpose was to describe literature in which positive correlations have been reported between ERN magnitude and the variables of diagnosis, neuropsychological test data, and medication regimens. Differences in error monitoring as indexed by ERN across different psychiatric illnesses and its clinical implications are discussed in terms of neural processes and psychopharmacology.

Keyword

Event-related potentials; Error-related negativity; Error monitoring; Autism; Schizophrenia; Obsessive-compulsive disorder

MeSH Terms

Autistic Disorder
Electroencephalography
Evoked Potentials
Humans
Neuropsychological Tests
Obsessive-Compulsive Disorder
Psychopharmacology
Schizophrenia