Korean J Psychopharmacol.
2008 Sep;19(5):256-265.
Effect of Long-Term Aripiprazole Therapy on Social Functioning in Korean Patients with Schizophrenia: A 52-Week, Prospective, Open-Label Study
- Affiliations
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- 1Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea. kwonjs@plaza.snu.ac.kr
- 2Department of Psychiatry, Hallym University, College of Medicine Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
- 3Department of Psychiatry, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea.
- 4Department of Psychiatry, Yonsei University College of Medicine, Severance Mental Health Hospital, Seoul, Korea.
- 5Department of Psychiatry, Gachon University Gil Hospital, Incheon, Korea.
- 6Department of Psychiatry, Yonsei University College of Medicine, Yongdong Severance Hospital, Seoul, Korea.
- 7Department of Psychiatry, Inha University College of Medicine, Incheon, Korea.
- 8Department of Psychiatry, Wonkwang University College of Medicine, Iksan, Korea.
- 9Department of Psychiatry, Chungnam National University, College of Medicine, Daejeon, Korea.
- 10Department of Psychiatry, Chungbuk National University College of Medicine, Cheongju, Korea.
- 11Department of Psychiatry, Kyungpook National University School of Medicine, Daegu, Korea.
Abstract
OBJECTIVE
We examined the effect of long-term aripiprazole therapy on social functioning in Korean patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder.
METHODS
In this 52-week open-label, multicenter, single-arm study, 300 Korean patients with schizophrenia were treated with aripiprazole 10-30 mg/day after administration of 15 mg/day during the first 2 weeks. The primary efficacy measure was the Korean-Social Functioning Scale (SFS-K), and the secondary efficacy measures were the Emotion Assessment, and the Positive and Negative Syndrome Scale (PANSS) score and the Clinical Global Impression - Severity of Illness (CGI-S) to investigate for correlation between social functioning and clinical symptoms.
RESULTS
At week 52, there were significant improvements in all the areas of the SFS-K. There was generally no difference in the change of social functioning between patients in the first episode and patients having previous episodes. Significant improvements were also observed in negative emotion and emotional control. Statistically significant correlation between the SFS-K and the PANSS score was observed at week 52.
CONCLUSION
The present study showed that long-term treatment with aripiprazole contributed to significant improvement in social functioning in patients with schizophrenia in the long-term treatment. This improvement of social functioning was modestly associated with clinical improvement of symptoms. The results suggest that long-term aripiprazole therapy could be effective not only in treating clinical symptoms, but also in improving social functioning in patients with schizophrenia-spectrum disorder.
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