Korean J Psychopharmacol.
2006 Mar;17(2):162-173.
The Feasibility Test of Korean Medication Algorithm for the Treatment with Schizophrenic Patients(IV): Influences of a History of Antipsychotic Treatment on Effectiveness and Algorithm Application
- Affiliations
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- 1Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea. hslee96@yumc.yonsei.ac.kr
- 2Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
- 3Department of Psychiatry, College of Medicine, Catholic University, Seoul, Korea.
- 4Department of Neuropsychiatry, College of Medicine, Chung-Ang University, Seoul, Korea.
- 5Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, Korea.
- 6Department of Psychiatry, Hallym University College of Medicine, Anyang, Korea.
- 7Department of Neuropsychiatry, College of Medicine, WonKwang University, Iksan, Korea.
- 8St. Andrewe's Neuropsychiatric Hospital, Icheon, Korea.
- 9Korean College of Neuropsychopharmacology and Korean Academy of Schizophrenia, Korea.
Abstract
OBJECTIVE
The Korean Medication Algorithm for the Treatment of Schizophrenia was developed by the extensive review and questionnaires. To evaluate the impact of a history of antipsychotic treatments on clinical response and algorithm application, using the data derived from the feasibility study of the Medication Algorithm for patients with schizophrenia. METHOD: Outcomes of treatment with the Medication Algorithm for 108 schizophrenics up to 4 months are presented. Measures of changes included clinical symptoms, functioning, and side effects. Comparison was done between patients with and without a history of antipsychotic treatments.
RESULTS
100 individuals (with a history=71 ; without a history=29) were analyzed for the comparison. Most of subjects without a history of antipsychotic treatments were administered on risperidone in the initial treatment. When compared with the subjects with a treatment history, the subjects without a history showed better treatment effects on clinical symptoms at the first evaluation. At 4-month, there were similar effects between the two groups except negative symptoms, in which the group with a history showed significantly more improvement than without a history. There were no significant differences in assessment of subjective opinion and well-being to drugs and quality of life, and objective evaluation of drug side effects. Among the subjects with a history, the ones starting with stage 1 showed higher positive symptoms, anxiety scores, and briefer duration of antipsychotic exposure than the ones starting with stage 2 or more advanced.
CONCLUSION
This study suggests that despite some limitation, an antipsychotic treatment history may have an impact on application of medication algorithm and these data will be helpful for revision of the Medication Algorithm for the Treatment of Schizophrenia.
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