Korean J Psychopharmacol.  2007 Jul;18(4):246-250.

Elevation of Serum Creatine Kinase Level in a Patient Treated with Atypical Antipsychotics: A Case Report

• Kim S
• Lim JH
• Kim CY

Abstract

We report a case of serum creatine kinase (CK) elevation in a 42-year-old man with schizoaffective disorder treated with olanzapine, aripiprazole, quetiapine, and modified electroconvulsive therapy (ECT). To elucidate the clinical meaning of serum CK elevation, we repeatedly measured psychotic severity and chemical data, including serum CK, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and cholesterol. Pearson's correlation analysis was performed between each measurement. The peak CK level during hospitalization was correlated with Clinical Global Impression (CGI) severity. Dissociation of CK level and myoglobinuria was observed, and elevated did not result in renal failure or any renal decompensation. Medication change among atypical antipsychotics could not terminate CK level, which did not seem to be associated with dosage or duration of use. The patient's mother showed similar CK level, which suggests genetic control of serum CK. Repeated measurement of serum CK is recommended for determining the clinical significance of CK level, which is not yet clear.

Keyword

Creatine kinase; Atypical antipsychotics; Olanzapine; Aripiprazole; Quetiapine; ECT

MeSH Terms

Adult
Alanine Transaminase
Antipsychotic Agents*
Aspartate Aminotransferases
Cholesterol
Creatine Kinase*
Creatine*
Electroconvulsive Therapy
Hospitalization
Humans
Mothers
Myoglobinuria
Psychotic Disorders
Renal Insufficiency
Aripiprazole
Quetiapine Fumarate
Alanine Transaminase
Antipsychotic Agents
Aspartate Aminotransferases
Cholesterol
Creatine
Creatine Kinase