Korean J Psychopharmacol.
2005 Jul;16(4):292-300.
Feasibility of Korean Medication Algorithm for Bipolar Disorder(III): Treatment Response and Tolerability
- Affiliations
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- 1Department of Psychiatry, Ilsan Hospital, National Health Insurance Corporation, Goyang, Korea.
- 2Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Psychiatry, College of Medicine, Catholic University, Seoul, Korea. wmbahk@catholic.ac.kr
- 4Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, Korea.
- 5Department of Neuropsychiatry, College of Medicine, Chung-Ang University, Seoul, Korea.
- 6Naju National Hospital, Naju, Korea.
- 7Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
- 8Korean College of Neuropsychopharmacology and Korean Academy of Schizophrenia, Korea.
Abstract
OBJECTIVE
The Korean College of Neuropsychopharmacology and the Korean Academy of Schizophrenia developed the Korean algorithm project for bipolar disorder to aid clinical decisions. The purpose of this study was to assess the treatment response and the tolerability in the feasibility testing of Korean Medication Algorithm for Bipolar Disorder (KMAP-BP) in clinical settings. METHODS: A total of 126 bipolar patients were enrolled at 17 centers. Among them, 92 patients were treated according to the algorithm. All subjects were assessed over a 4-month period. Prescribing investigators were able to change the recommended treatment strategies of the algorithm if necessary. RESULTS: Most patients showed significant decreases (p<0.001) in symptoms measured by the Young Mania Rating Scale and the 17-item Hamilton Depression Rating Scale for Depression at both assessment point 1 (about 2 weeks) and 4 months. No significant changes in adverse events were noted between baseline and endpoint. CONCLUSION: These results suggest that the treatment based on KMAP-BP can be effective and well tolerated in clinical practices. Further research is planned to revise KMAP-BP.
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