Korean J Thorac Cardiovasc Surg.  2016 Jun;49(3):157-164. 10.5090/kjtcs.2016.49.3.157.

Clinical Outcomes of Heart-Lung Transplantation: Review of 10 Single-Center Consecutive Patients

• Yun JK
• Choi SH
• Park SI
• Asan Medical Center Heart-Lung Transplantation Team

• KMID: 2285803
• DOI: http://doi.org/10.5090/kjtcs.2016.49.3.157

Abstract

BACKGROUND
Heart-lung transplantation (HLT) has provided hope to patients with end-stage lung disease and irreversible heart dysfunction. We reviewed the clinical outcomes of 10 patients who underwent heart-lung transplantation at Asan Medical Center.
METHODS
Between July 2010 and August 2014, a total of 11 patients underwent HLT at Asan Medical Center. After excluding one patient who underwent concomitant liver transplantation, 10 patients were enrolled in our study. We reviewed the demographics of the donors and the recipients' baseline information, survival rate, cause of death, and postoperative complications. All patients underwent follow-up, with a mean duration of 26.1±16.7 months.
RESULTS
Early death occurred in two patients (20%) due to septic shock. Late death occurred in three patients (38%) due to bronchiolitis obliterans (n=2) and septic shock (n=1), although these patients survived for 22, 28, and 42 months, respectively. The actuarial survival rates at one year, two years, and three years after HLT were 80%, 67%, and 53%, respectively.
CONCLUSION
HLT is a procedure that is rarely performed in Korea, even in medical centers with large heart and lung transplant programs. In order to achieve acceptable clinical outcomes, it is critical to carefully choose the donor and the recipient and to be certain that all aspects of the transplant procedure are planned in advance with the greatest care.

Keyword

Heart-lung transplantation; Complication; Mortality

MeSH Terms

Bronchiolitis Obliterans
Cause of Death
Chungcheongnam-do
Demography
Follow-Up Studies
Heart
Heart-Lung Transplantation*
Hope
Humans
Korea
Liver Transplantation
Lung
Lung Diseases
Mortality
Postoperative Complications
Shock, Septic
Survival Rate
Tissue Donors