Korean J Physiol Pharmacol.
1999 Jun;3(3):283-291.
Selective cytotoxicity of a novel platinum (II) coordination complex on human gastric cancer cell lines and normal kidney cells
- Affiliations
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- 1Department of Pharmacology, School of Medicine, Kyung Hee University, Hoeki-dong, Dongdaemoon-ku, Seoul, 130-701 South Korea.
- 2Urology, School of Medicine, Kyung Hee University, Hoeki-dong, Dongdaemoon-ku, Seoul, 130-701 South Korea.
- 3Department of Biochemistry, Kyung Hee University, Hoeki-dong, Dongdaemoon-ku, Seoul, 130-701 South Korea.
- 4Pharmacochemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea.
Abstract
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We have synthesized novel platinum (II) coordination complex containing
cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and
1,2-bis(diphenylphosphino)ethane (DPPE) as leaving group. Furthermore,
nitrate was added to improve the water-solubility. A new series of
(Pt(cis-DACH)(DPPE)) cntdot 2NO3 (PC) was evaluated its antitumor
activity on various MKN-45 human gastric adenocarcinoma cell-lines and
normal primary cultured kidney cells. The new platinum complex
demonstrated high efficacy in the cytotoxicity on MKN-45 cell-lines as
well as adriamycin-resistant (MKN-45/ADR) and cisplatin-resistant
(MKN-45/CDDP) cells. The cytotoxicities of PC were found quite less
than those of cisplatin in rabbit proximal renal tubular cells, human
renal cortical cells and human renal cortical tissues using MTT assay,
(3H)-thymidine uptake and glucose consumption tests. Based on these
results
, this novel platinum (II) coordination complex, was considered as better a valuable lead for improving antitumor activities with low nephrotoxicities in the development of a new clinically available anticancer chemotherapeutic agents.
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