Infect Chemother.
2005 Feb;37(1):16-21.
Multi-center Study on Cost Effectiveness of Anti-Tuberculosis Drug Susceptibility Test
- Affiliations
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- 1Department of Laboratory Medicine, Kosin University College of Medicine, Busan, Korea.
- 2Department of Laboratory Medicine, College of Medicine, Pusan National University, Busan, Korea. cchl@pusan.ac.kr
- 3Department of Laboratory Medicine, School of Medicine, Gyeongsang National University, Jinju, Korea.
- 4Department of Laboratory Medicine, College of Medicine, Inje University, Busan Paik Hospital, Busan, Korea.
- 5Department of Laboratory Medicine, College of Medicine, Ulsan University, Ulsan, Korea.
- 6Korean Institute of Tuberculosis, The Korean National Tuberculosis Association, Seoul, Korea.
- 7Medical Research Institute, Pusan National University, Busan, Korea.
Abstract
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BACKGROUND: The anti-mycobacterial susceptibility test is performed on only a small percentage of clinical isolates in Korea. The aim of this study is to propose an anti-mycobacterial susceptibility testing scheme, which is not only economic and practical but also fully informative to physicians.
MATERIALS AND METHODS
The anti-mycobacterial susceptibility test results of 502 strains, isolated from five university-affiliated hospitals, were analysed. The interpretation of the results and the need for second-line drug susceptibility test were judged according to the recommendation of NCCLS M24-A guidelines.
RESULTS
The isolates from 10% (38/363) of treatment-navie patients and 61% (85/139) of re- treatment patients showed resistance to at least one of the anti-mycobactial agents; 3% (11/363) and 44% (61/139) of isolates from each group were multi-drug resistant. According to the recommendation by NCCLS, the percentage of patients not needing the susceptibility test results for second-line drugs were 96% for treatment-naive and 47% for re-treatment patients.
CONCLUSION
Since the susceptibility test against first-line drug is sufficient for 95% of treatment- navie patients with tuberculosis patients, susceptibility test against second-line drugs may be performed only when it is necessary. As for the re-treatment patients with tuberculosis, susceptibility test for both first-line and second-line drugs should be performed simultaneously.
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