Infect Chemother.  2013 Jun;45(2):117-136. 10.3947/ic.2013.45.2.117.

Genomic Basis for Methicillin Resistance in Staphylococcus aureus

Affiliations
  • 1Department of Bacteriology, Juntendo University, Tokyo, Japan. khiram06@juntendo.ac.jp
  • 2Research Center for Infection Control Science, Juntendo University, Tokyo, Japan.
  • 3Department of Veterinary Science, Rakuno Gakuen University, Hokkaido, Japan.
  • 4National Institute of Infectious Diseases, Tokyo, Japan.

Abstract

Since the discovery of the first strain in 1961 in England, MRSA, the most notorious multidrug-resistant hospital pathogen, has spread all over the world. MRSA repeatedly turned down the challenges by number of chemotherapeutics, the fruits of modern organic chemistry. Now, we are in short of effective therapeutic agents against MRSA prevailing among immuno-compromised patients in the hospital. On top of this, we recently became aware of the rise of diverse clones of MRSA, some of which have increased pathogenic potential compared to the classical hospital-associated MRSA, and the others from veterinary sources. They increased rapidly in the community, and started menacing otherwise healthy individuals by causing unexpected acute infection. This review is intended to provide a whole picture of MRSA based on its genetic makeup as a versatile pathogen and our tenacious colonizer.

Keyword

oriC environ; SCCmec; mecA; mecB; mecC; rpoB; Hetero-resistance

MeSH Terms

Adenosine
Chemistry, Organic
Chromatography, Micellar Electrokinetic Capillary
Clone Cells
Colon
England
Fruit
Humans
Methicillin
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Sprains and Strains
Staphylococcus
Staphylococcus aureus
Adenosine
Methicillin
Full Text Links
  • IC
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error