Gut Liver.  2011 Dec;5(4):478-485.

Factors Predicting the Efficacy of Adefovir Dipivoxil on Treatment-Naive Chronic Hepatitis B Patients at 48 Weeks

• Wang LC
• Chen EQ
• Zhu XF
• Xiong ZH
• Liu L
• Xu L
• Lei XZ
• Liu C
• Tang H

Abstract

BACKGROUND/AIMS
To reveal possible factors predicting the effect of adefovir dipivoxil (ADV) treatment on chronic hepatitis B (CHB) and optimize the utilization of ADV.
METHODS
In total, 168 treatment-naive CHB patients were enrolled, including 117 hepatitis B e antigen (HBeAg)-positive patients and 51 HBeAg-negative patients who met the inclusion criteria. All patients were treated with ADV 10 mg per day for 48 weeks. Multiple logistic regression analyses were used to investigate baseline factors, and responses at weeks 12 and 24 were analyzed as predictive values.
RESULTS
Multiple regression analyses showed that baseline HBeAg status and HBV DNA levels significantly affected the virological response (VR) (p<0.05), baseline ALT levels were an independent predictor of serological response (SR) (p<0.05) and the body mass index (BMI) may affect the biochemical response (BR) (p<0.05). There was a statistically significant difference in the VR and SR between patients with a primary nonresponse (PNR) at week 12 and those with a VR at week 12 (p<0.01). Additionally, the VR was significantly different between patients with HBV DNA lower than 103 copies/mL at week 24 and those with greater than 103 copies/mL (p<0.01).
CONCLUSIONS
Patients with negative HBeAg, lower HBV DNA levels and higher ALT values at baseline are more suitable for ADV treatment, whereas patients with lower BMIs may be more amenable to ALT normalization. Adjustments for treatment strategy should be considered if PNR at week 12 or HBV DNA > or =10(3) copies/mL at week 24 is observed.

Keyword

Adefovir dipivoxil; Antiviral therapy; Chronic hepatitis B; Predictive factors

MeSH Terms

Adenine
Body Mass Index
DNA
Hepatitis B
Hepatitis B e Antigens
Hepatitis B, Chronic
Hepatitis, Chronic
Humans
Logistic Models
Organophosphonates
Adenine
DNA
Hepatitis B e Antigens
Organophosphonates