Gut Liver.
2010 Jun;4(2):266-269.
Pathological Complete Remission of Advanced Hepatocellular Carcinoma with Main Portal Vein Tumor Thrombosis by Hepatic Arterial Infusion Chemotherapy
- Affiliations
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- 1Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. dreun@ynu.ac.kr
- 2Department of Radiology, Yeungnam University College of Medicine, Daegu, Korea.
- 3Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea.
- 4Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea.
Abstract
- Cures for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) are rare and difficult. We report a case of pathologically confirmed complete remission of HCC induced by hepatic arterial infusion chemotherapy (HAIC). A 45-year-old male patient had a massive HCC in the right lobe of the liver and tumor thrombus in the right and main portal veins. He achieved a partial response after two cycles of HAIC with 5-fluorouracil (750 mg/m2) and cisplatin (25 mg/m2). After the completion of six cycles he received a curative partial hepatectomy, and histopathology revealed complete necrosis without any viable tumor cell. He was in good health at a 4-month follow-up. These results suggest that this regimen is a promising therapeutic modality for the treatment of advanced HCC with PVTT.
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