Korean J Prev Med.  1999 Dec;32(4):491-493.

Meta-analysis on the Blood Lipids as Risk Factors of Coronary Heart Diseases in Koreans

• Ryu SY
• Kim KS
• Kim YO
• Park J
• Park JK
• Kim CB
• Jee SH

Abstract

OBJECTIVES
To determine the relations between seven blood lipids such as total cholesterol(TC), triglyceride(TG), HDL-cholesterol(HDL), LDL-cholesterol(LDL), apolipoprotein A-1(Apo A1), apolipoprotein B(Apo B) and lipoprotein(a)(Lp(A)) and the coronary heart diseases(CHD), the quantitative techniques of meta-analysis were applied to studies of blood lipids and CHD in Koreans.
METHODS
We searched the Korean and the English literature published from 1980 to August, 1997 by manual search and bibliography review. Information on sample size, study design, participant characteristics(gender, age) and blood lipid levels were abstracted by reviewers using inclusion criteria. Estimates of the effect sizes of blood lipid levels on CHD in Koreans and corresponding 95% confidence intervals were calculated using random-effect models.
RESULTS
We identified 16 case-control studies to apply meta-analysis. The overall effect sizes for CHD were 20.3(95% CI : 14.23-26.22) in TC, 24.8(95% CI : 12.6-36.86) in TG, 15.16(95% CI : 3.99 - 26.33) in LDL, -3.48(95% CI : -5.79 - -1.17) in HDL, -9.78(95% CI : -16.98 - -2.58) in Apo-a1, 17.88(95% CI : 9.72 - 26.05) in Apo B and 18.95(95% CI : 17.88 - 20.02) in Lp(a).
CONCLUSIONS
Our results suggested that seven blood lipids were significantly associated with CHD in Koreans. Well-designed and prospective studies between blood lipids and CHD in Koreans should be performed.

Keyword

Coronary heart disease; Blood lipid; Korean; Meta-analysis

MeSH Terms

Apolipoproteins
Apolipoproteins B
Case-Control Studies
Coronary Disease*
Heart
Risk Factors*
Sample Size
Apolipoproteins
Apolipoproteins B