Korean J Pediatr.  2009 Aug;52(8):893-897. 10.3345/kjp.2009.52.8.893.

The effects of neonatal ventilator care or maternal chorioamnionitis on the development of bronchopulmonary dysplasia

• Yun KT
• Lee WD
• Lee SG

• KMID: 2281588
• DOI: http://doi.org/10.3345/kjp.2009.52.8.893

Abstract

PURPOSE
Advances in neonatal intensive care have improved the survival rate of low-birth-weight infants, but mild bronchopulmonary dysplasia (BPD) with the accompanying need for prolonged oxygen supplement remains problematic. Maternal chorioamnionitis and neonatal ventilator care affect the development of BPD. This study aimed to examine whether maternal chorioamnionitis or neonatal ventilator care affect the development of BPD dependently or independently. METHODS: We performed a retrospective study of 158 newborn infants below 36 weeks of gestational age and 1,500 gm birth weight admitted to the neonatal intensive care unit of Daegu Fatima Hospital between January 2000 and December 2006. We analyzed the incidence of BPD according to maternal chorioamnionitis and neonatal ventilator care. Result: Histologic chorioamnionitis was observed in 50 of 158 infants (31.6%). There were no significant differences in the development of BPD (P=0.735) between the chorioamnionitis (+) and chorioamnionitis (-) groups. In the multiple regression analysis, ventilator care (OR=7.409, 95% CI=2.532-21.681) and neonatal sepsis (OR=4.897, 95% CI=1.227-19.539) affected the development of BPD rather than maternal chorioamnionitis (OR=0.461, 95% CI=0.201-1.059). CONCLUSION: Ventilator care or neonatal sepsis may play a role in the development of BPD rather than maternal chorioamnionitis.

Keyword

Chorioamnionitis; Mechanical ventilators; Bronchopulmonary dysplasia

MeSH Terms

Birth Weight
Bronchopulmonary Dysplasia
Chorioamnionitis
Female
Gestational Age
Humans
Incidence
Infant
Infant, Low Birth Weight
Infant, Newborn
Intensive Care, Neonatal
Oxygen
Pregnancy
Retrospective Studies
Sepsis
Survival Rate
Ventilators, Mechanical
Oxygen