Korean J Pediatr.
2009 Nov;52(11):1249-1259. 10.3345/kjp.2009.52.11.1249.
Economic evaluation of a weekly administration of a sustained-release injection of recombinant human growth hormone for the treatment of children with growth hormone deficiency
- Affiliations
-
- 1Graduate School of Public Health, Institute of Health Services Research, Yonsei University, Seoul, Korea. hykang@yuhs.ac
- 2Department of Pediatrics, Severance Children's Hospital, Yonsei University, Seoul, Korea.
- 3Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea.
- 4Graduate School of Public Health, Yonsei University, Seoul, Korea.
- KMID: 2281030
- DOI: http://doi.org/10.3345/kjp.2009.52.11.1249
Abstract
- PURPOSE
From a societal perspective, we evaluated the cost-effectiveness of a novel sustained-release injection of recombinant human growth hormone (GH) administered on a weekly basis compared with that of the present daily GH injection for the treatment of children with GH deficiency. METHODS: Health-related utility for GH therapy was measured based on the visual analogue scale. During July 2008, caregivers of 149 children receiving GH therapy form 2 study sites participated in a web-based questionnaire survey. The survey required the caregivers to rate their current subjective utility with daily GH injections or expected utility of weekly GH injections. Because there was no difference in the costs of the daily and weekly therapies, for the purposes of this study, only drug acquisition costs were considered. RESULTS: Switching from daily to weekly injection of GH increased the utility from 0.584 to 0.784 and incurred an extra cost of 4,060,811 Korean won (KW) per year. The incremental cost-utility ratio (ICUR) for a base case was 20,305,055 KW per quality-adjusted life year (QALY) gained. Scenario analyses showed that the ICUR ranged from 15,751,198 to 25,489,929 KW per QALY. CONCLUSION: The ICUR for a base case and worst case scenario analyses ranged from 0.85 to 1.37-times per capita gross domestic product of Korea, which is considered to be within the generally accepted willingness-to-pay threshold. Thus, it is concluded that switching from daily to weekly injection of GH would be cost-effective.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Effect of yeast-derived methionyl recombinant growth hormone on growth hormone deficient dwarf
- Clinical effects of yeast derived recombinant methionyl growth hormone in growth hormone deficiency
- The pharmacokinetics and biological effects of yeast derived recombinant methionyl growth hormone in growth hormone deficient children
- Efficacy and Safety of Sustained-Release Recombinant Human Growth Hormone in Korean Adults with Growth Hormone Deficiency
- Quantification of human urinary growth hormone and its clinical significance in the diagnosis of growth hormone deficiency
