Korean J Perinatol.  2012 Dec;23(4):286-291.

A Case of Neonate with Acute Renal Failure after Maternal Treatment with Angiotensin II Receptor Blocker

• Ra JJ
• Eun HS
• Lee SM
• Park MS
• Namgung R
• Lee C
• Park KI

Abstract

Hypertension is common medical problem encountered during pregnancy. However medication administered for maternal hypertension may cause fetal or neonatal complications. Angiotensin converting enzyme inhibitor or angiotensin II receptor blocker are rarely used during pregnancy, and there are few reports about the effect of them, because administration of these drugs during pregnancy may cause oligohydramnios, renal tubular dysplasia, hypocalvaria, pulmonary hypoplasia, intrauterine growth retardation, neonatal anuria and persistent ductus arteriosus. We report a case of neonatal acute renal failure by angiotensin II receptor blocker during pregnancy. In this case, the neonate with meconium aspiration was admitted to neonatal intensive care unit (NICU). During the NICU stay, neonatal anuria occurred, and there was a medical history that his mother took Candesartan Cilexeril (Atacand(R)), one of angiotensin II receptor blockers during pregnancy. The neonate showed intrinsic acute renal failure, so fluid was restricted and diuretics were administered to the neonate, and after 10 days, anuria improved.

Keyword

Angiontensin II receptor blocker; Anuria; Acute renal failure; Maternal exposure; Infant; Newborn

MeSH Terms

Acute Kidney Injury
Angiotensin II
Angiotensin Receptor Antagonists
Angiotensins
Anuria
Benzimidazoles
Diuretics
Ductus Arteriosus
Female
Fetal Growth Retardation
Humans
Hypertension
Infant
Infant, Newborn
Intensive Care, Neonatal
Maternal Exposure
Meconium Aspiration Syndrome
Mothers
Oligohydramnios
Peptidyl-Dipeptidase A
Pregnancy
Receptors, Angiotensin
Tetrazoles
Angiotensin II
Angiotensin Receptor Antagonists
Angiotensins
Benzimidazoles
Diuretics
Peptidyl-Dipeptidase A
Receptors, Angiotensin
Tetrazoles