Mood Emot.  2023 Jul;21(2):. 10.35986/me.2023.21.2.28.

Lithium Toxicity during Hypertension Treatment Using Angiotensin II Receptor Blocker in a Patient with Bipolar Disorder

• Lee SW
• Yang CM
• Lee SY
• Jang SH

• KMID: 2551135
• DOI: http://doi.org/10.35986/me.2023.21.2.28

Abstract

Herein, we present a case of lithium intoxication in a patient with bipolar disorder who was concurrently using an angiotensin II receptor blocker (ARB). Lithium, commonly prescribed for mental illnesses, possess a narrow therapeutic range (0.6-1.2 mmol/L) and can be influenced by medications that alter renal function. Interactions with other drugs, such as ARBs and chlorothiazide, can exacerbate lithium toxicity by influencing the sodium channel. This may lead to increased lithium reabsorption followed by toxicity and dehydration. This study highlights the importance of closely monitoring patients on lithium when co-administering medications that can impact lithium metabolism.

Keyword

Lithium; Antihypertensive agents; Angiotensin receptor antagons