Diabetes Metab J.  2015 Feb;39(1):66-73. 10.4093/dmj.2015.39.1.66.

Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome

• Gyawali P
• Takanche J
• Shrestha R
• Bhattarai
• Khanal K
• Risal P
• Koju R

• KMID: 2280659
• DOI: http://doi.org/10.4093/dmj.2015.39.1.66

Abstract

BACKGROUND
Thyroid dysfunction (TD) and metabolic syndrome (MetS) are known risk factors for atherosclerotic cardiovascular disease (ASCVD). TD is risk factor for ASCVD mediated by the effects of thyroid hormones on lipid metabolism and blood pressure hence the components of MetS. It is possible that coexistence of these two disease entities and unrecognized TD in patients with MetS might substantially increase ASCVD risk. Moreover, little is known about the relationship between TD and the components of MetS. Thus, the purpose of this study was to evaluate the pattern of TD in patients with MetS and its relationship with components of the MetS.
METHODS
A total of 358 previously diagnosed patients with MetS were recruited in the study. The thyroid function test parameters were measured to classify TD at Dhulikhel Hospital-Kathmandu University Hospital, Dhulikhel, Nepal. Statistical analyses were performed using SPSS version 16.0 to evaluate pattern and relationship.
RESULTS
The overall prevalence of TD in patients with MetS was 31.84% with high prevalence of subclinical hypothyroidism (29.32%). We found no evidence of a relationship between TD and components of MetS, although there was significant difference in waist circumference between four groups of TD.
CONCLUSION
Patients with MetS had subclinical hypothyroidism greatly. Although there was no evidence of any relationship between thyroid status and all components of MetS, TD should be taken into account when evaluating and treating patients with MetS to reduce the impending risk.

Keyword

Atherosclerotic cardiovascular disease risk; Metabolic syndrome; Subclinical hypothyroidism; Thyroid dysfunction

MeSH Terms

Blood Pressure
Cardiovascular Diseases
Humans
Hypothyroidism
Lipid Metabolism
Nepal
Prevalence
Risk Factors
Thyroid Function Tests
Thyroid Gland*
Thyroid Hormones
Waist Circumference
Thyroid Hormones

Figure

• 

  Fig. 1 Pattern of thyroid dysfunction in patients with metabolic syndrome (n=358).

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