Korean J Geriatr Gerontol.  2014 Jun;15(1):14-19. 10.15656/kjcg.2014.15.1.14.

Relationship between Serum TSH Level within the Normal Reference Range and the Metabolic Syndrome

• Shin HS
• Kim JR
• Seo JY
• Shin KS
• Yoo BW
• Cho YJ
• Oh JE
• Hong SH
• Cho CY

• KMID: 2566522
• DOI: http://doi.org/10.15656/kjcg.2014.15.1.14

Abstract

Background
Several studies have shown that the risk of cardiovascular disease is elevated by the metabolic syndrome and thyroid hormone. Thus, it is necessary to access the relation of thyroid hormone and the risk factor of cardiovascular disease. The aim of the present study is to evaluate the association between serum thyroid-stimulating hormone (TSH) and the metabolic syndrome.
Methods
Subjects for this cross-sectional study were 5,526 men and women aged 20 years and more, who visited the health promotion center of one university hospital in Chungcheongnam-do for general health check-up from February 2010 to February 2011. Study people with normal TSH level divided into four groups according to serum TSH level quartiles. Age, body mass index (BMI), blood pressure (BP), fasting glucose, total cholesterol, triglyceride and high-density lipoprotein cholesterol (HDL-C) were compared with serum TSH concentration. The contribution of parameters of the metabolic syndrome in subjects with TSH level was assessed.
Results
Serum TSH level related with diastolic BP, systolic BP, and fasting glucose level (P＜0.05). But the other components showed no difference among the groups. TSH was not related with the metabolic syndrome.
Conclusion
There was no association between serum TSH level and metabolic syndrome in healthy euthyroid subjects.

Keyword

Thyroid-stimulating hormone; Metabolic syndrome