Clin Pediatr Hematol Oncol.
2014 Apr;21(1):41-45.
A Case of Osteosarcoma after Treatment of Endodermal Sinus Tumor
- Affiliations
-
- 1Department of Pediatrics, Korea University College of Medicine, Seoul, Korea. kwcl5609@korea.ac.kr
- 2Department of Pathology, Korea University College of Medicine, Seoul, Korea.
Abstract
- Endodermal sinus tumor is a type of germ cell tumor that is relatively common in children. An important problem concerns secondary neoplasms after treatment. We report a case of osteosarcoma that developed five years after treatment of intrapelvic endodermal sinus tumor. The patient was a seven-year-old girl who presented with right thigh and knee joint pain. The patient had been diagnosed with endodermal sinus tumor five years previously and treated with a regimen consisting of high dose cisplatin, etoposide, bleomycin and surgery but without radiotherapy. We detected a mass shadow on the right distal femur that proved to be osteoblastic osteosarcoma by incisional biopsy. The patient received surgical treatment after chemotherapy that included high dose methotrexate. The follow-up bone scan revealed no abnormal uptakes. There has been no evidence of recurrence eighteen months of follow-up after chemotherapy.
