Korean J Pediatr Infect Dis.  2013 Aug;20(2):98-104.

Two Pediatric Cases of Dengue Fever Imported from Philippines

• Oh MA
• Shim JW
• Kim DS
• Jung HL
• Park MS
• Shim JY

Abstract

Dengue fever is an important health problem for international travelers to all endemic areas. The steadily increasing numbers of tourists visiting endemic areas raise the risk of exposure, and imported dengue cases are increasingly observed in nonendemic area. Dengue has a wide spectrum of clinical presentations, often with unpredictable clinical evolution and outcome. While most patients recover following a self-limiting, non-severe clinical course, a small proportion progress to severe disease such as dengue hemorrhagic fever or dengue shock syndrome. Therefore, it is important to suspect dengue fever in every febrile patient returning from the tropics. Whenever it is suspected, a quick diagnosis and adequate managements are essential to avoid complications. We report two cases of imported dengue fever in Korean children presenting with fever, headache, nausea, and rash.

Keyword

Dengue; Korea; Child; Travel

MeSH Terms

Child
Dengue
Dengue Hemorrhagic Fever
Exanthema
Fever
Headache
Humans
Korea
Nausea
Philippines

Reference

1. World Health Organization. Dengue: guidelines for diagnosis, treatment, prevention and control. World Health Organization Press;2009.

2. Gubler DJ. The global emergence/resurgence of arboviral diseases as public health problems. Arch Med Res. 2002; 33:330–342.

3. Simmons CP, Farrar JJ, Nguyen vV, Wills B. Dengue. N Engl J Med. 2012; 366:1423–1432.

4. Stienlauf S, Segal G, Sidi Y, Schwartz E. Epidemiology of travel-related hospitalization. J Travel Med. 2005; 12:136–141.

5. Korea Centers for Disease Control and Prevention. Trends in imported cases of infectious diseases in Korea. Public Health Weekly Report. KCDC;2008. p. 1.

6. Guzman MG, Kouri G, Bravo J, Valdes L, Vazquez S, Halstead SB. Effect of age on outcome of secondary dengue 2 infections. Int J Infect Dis. 2002; 6:118–124.

7. O'Brien DP, Leder K, Matchett E, Brown GV, Torresi J. Illness in returned travelers and immigrants/refugees: the 6-year experience of two Australian infectious diseases units. J Travel Med. 2006; 13:145–152.

8. Gibbons RV, Vaughn DW. Dengue: an escalating problem. BMJ. 2002; 324:1563–1566.

9. Barrera R, Amador M, MacKay AJ. Population dynamics of Aedes aegypti and dengue as influenced by weather and human behavior in San Juan, Puerto Rico. PLoS Negl Trop Dis. 2011; 5:e1378.

10. Halstead SB. Dengue virus-mosquito interactions. Annu Rev Entomol. 2008; 53:273–291.

11. Lee CJ, Kim HR, Kim MJ. A case of imported dengue hemorrhagic fever. Korean J Infect Dis. 1995; 27:403–406.

12. Choi HH, Park JA, Kim JS, Hur YJ, Song MS, Hwang TG, et al. A case of an imported dengue hemorrhagic fever with spontaneous bleeding: case report and review of the literature. Korean J Pediatr Infect Dis. 2011; 18:207–211.

13. Choi SH, Kim YJ, Shin JH, Yoo KH, Sung KW, Koo HH. International travel of Korean children and dengue fever: A single institutional analysis. Korean J Pediatr. 2010; 53:701–704.

14. Park HS, Kim KK, Yoon J, Lee KR, Suh HS. Two cases of dengue fever in family medicine. J Korean Acad Fam Med. 2008; 29:48–51.

15. Solomon T, Dung NM, Vaughn DW, Kneen R, Thao LT, Raengsakulrach B, et al. Neurological manifestations of dengue infection. Lancet. 2000; 355:1053–1059.

16. Cobra C, Rigau-Perez JG, Kuno G, Vorndam V. Symptoms of dengue fever in relation to host immunologic response and virus serotype, Puerto Rico, 1990-1991. Am J Epidemiol. 1995; 142:1204–1211.

17. Rigau-Perez JG, Clark GG, Gubler DJ, Reiter P, Sanders EJ, Vorndam AV. Dengue and dengue haemorrhagic fever. Lancet. 1998; 352:971–977.

18. Jelinek T, Muhlberger N, Harms G, Corachan M, Grobusch MP, Knobloch J, et al. Epidemiology and clinical features of imported dengue fever in Europe: sentinel surveillance data from TropNetEurop. Clin Infect Dis. 2002; 35:1047–1052.

19. Srikiatkhachorn A, Krautrachue A, Ratanaprakarn W, Wongtapradit L, Nithipanya N, Kalayanarooj S, et al. Natural history of plasma leakage in dengue hemorrhagic fever: a serial ultrasonographic study. Pediatr Infect Dis J. 2007; 26:283–290.

20. Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, et al. Early clinical and laboratory indicators of acute dengue illness. J Infect Dis. 1997; 176:313–321.

21. Harris E, Roberts TG, Smith L, Selle J, Kramer LD, Valle S, et al. Typing of dengue viruses in clinical specimens and mosquitoes by single-tube multiplex reverse transcriptase PCR. J Clin Microbiol. 1998; 36:2634–2639.

22. Chan SY, Kautner IM, Lam SK. The influence of antibody levels in dengue diagnosis by polymerase chain reaction. J Virol Methods. 1994; 49:315–322.

23. Schwartz E, Mileguir F, Grossman Z, Mendelson E. Evaluation of ELISA-based sero-diagnosis of dengue fever in travelers. J Clin Virol. 2000; 19:169–173.

24. Dung NM, Day NP, Tam DT, Loan HT, Chau HT, Minh LN, et al. Fluid replacement in dengue shock syndrome: a randomized, double-blind comparison of four intravenous-fluid regimens. Clin Infect Dis. 1999; 29:787–794.