Clin Exp Otorhinolaryngol.  2010 Mar;3(1):52-55.

Granular Cell Tumor on Larynx

• Park JH
• Do NY
• Cho SI
• Choi JY

Abstract

Granular cell tumors (GCTs) are uncommon neoplasm. They can originate in any part of the body. The most common sites of origin are in the head and neck, while the larynx is a relatively uncommon location. Patients affected with a laryngeal GCT typically present with persistent hoarseness, stridor, hemoptysis, dysphagia, and otalgia but, the tumor may be asymptomatic. Care must be taken to differentiate this lesion from others due to the presence of pseudo-epitheliomatous hyperplasia which overlies the GCT and may occasionally mimic squamous cell carcinoma. Therefore, a confirmative diagnosis should be made histopathologically and should be supported by immunohistochemical staining. These tumors are treated by complete surgical resection. Examining the complete removal of the tumor through securing a negative free margin is considered to be a consequential procedure. We experienced a 64-yr-old man with a laryngeal granular cell tumor involving the right true vocal cord. He was treated by surgical resection under a fine dissection laryngomicroscope. Here we present this case and a review of literature.

Keyword

Granular cell tumor; Larynx

MeSH Terms

Carcinoma, Squamous Cell
Deglutition Disorders
Earache
Granular Cell Tumor
Head
Hemoptysis
Hoarseness
Humans
Hydrazines
Hyperplasia
Larynx
Neck
Respiratory Sounds
Vocal Cords
Hydrazines

Figure

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  Fig. 1 (A) Preoperative direct laryngoscopic finding. An irregular margined mass occupying the right true vocal cord. (B) A laryngeal stroboscopic finding after the operation. The tumor was completely excised and no evidence of recurrence was found 1 yr after the operation.

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  Fig. 2 (A) The cells contain innumerable fine cytoplasmic granules (H&E, ×200). (B) The cytoplasm of tumor cells contains periodic acid-Schiff-positive materials (H&E, ×40). (C) S-100 immunohistochemical staining shows positive granular cells possessiveness, denoting its neuroectodermal origin (H&E, ×200). (D) Neuron-specific enolase immunohistochemical staining shows positive granular cells possessiveness, denoting its neuroectodermal origin (H&E, ×100). (E) Tumor cells revealed no immunoreactivity for smooth muscle actin (H&E, ×100).

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