Korean J Pathol.
2012 Oct;46(5):478-482.
Ghost Cell Odontogenic Carcinoma Arising from Calcifying Cystic Odontogenic Tumor: A Case Report
- Affiliations
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- 1Department of Pathology, West China Hospital of Stomatology, Sichuan University, Sichuan, China. chen_yuhx@163.com
- 2Department of Radiology, West China Hospital of Stomatology, Sichuan University, Sichuan, China.
Abstract
- Ghost cell odontogenic carcinoma (GCOC) is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics. We describe a case of GCOC which was considerably derived from a previously resected calcifying cystic odontogenic tumor (CCOT). Cellular atypia, mitotic activity, Ki-67 labeling index and matrix metalloprotease-9 positive expression rate were all increased in the currently resected specimen compared to the initial one. This is a rare case of malignant transformation of CCOT to GCOC with respect to its histopathological and immunohistochemical findings.
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