Korean J Otorhinolaryngol-Head Neck Surg.  2012 Feb;55(2):71-75. 10.3342/kjorl-hns.2012.55.2.71.

Human Papilloma Virus Positive Oropharyngeal Cancer

• Park JJ

• KMID: 2277318
• DOI: http://doi.org/10.3342/kjorl-hns.2012.55.2.71

Abstract

Human papilloma virus (HPV) is associated with the progression of head and neck squamous cell carcinoma (HNSCC), particularly tonsils and base of tongue. HPV (+) HNSCC represent a distinct disease entity from those are implicated in carcinogen. The molecular mechanism underlying HPV tumorgenesis are appreciated, with its two major oncogens E6 and E7, inactivating p53 and Rb, respectively. However, the ideal technique for HPV determination on archival material or tissue remains uncertain. This paper reviewed the epidemiology, clinical presentation, pathogenesis, diagnosis, therapy and prevention.

Keyword

Head and neck cancer; Human papilloma virus

MeSH Terms

Carcinogens
Carcinoma, Squamous Cell
Head
Head and Neck Neoplasms
Humans
Neck
Oropharyngeal Neoplasms
Palatine Tonsil
Papilloma
Tongue
Viruses
Carcinogens