Korean J Otorhinolaryngol-Head Neck Surg.  2010 Jan;53(1):7-11. 10.3342/kjorl-hns.2010.53.1.7.

Analysis of Relationship between the Dehydration Test and the Diuretics Treatment in Definite Meniere's Disease

• Chung SW
• Yoon JH
• Han GC

• KMID: 2277120
• DOI: http://doi.org/10.3342/kjorl-hns.2010.53.1.7

Abstract

BACKGROUND AND OBJECTIVES
Diuretics and dehydration tests are used for the main treatment of Meniere's disease as well as the predictor of the disease activity. We analyzed the relationship between the results of dehydration test and the effect of diuretics in patients with definite Meniere's disease.
SUBJECTS AND METHOD
Seventy patients with definite Meniere's disease were selected from January 1999 to June 2007 by reviewing the medical records, retrospectively. Fifty six patients underwent a glycerol test and thirty patients with the furosemide test before treatment. Hydrochlorothiazide was prescribed over twelve months.
RESULTS
The positive rates of glycerol and furosemide tests were 46.7% and 51.8%, respectively. The number of patients who kept the medication over twelve months were 62 (88.6%); those who showed complete remission (CR) were 10 (16.1%), partial remission (PR) 26 (41.9%) and no response (NR) 26 (41.9%). The positive rate of furosemide test was 60% in the patients with CR, 44.4% in patients with PR and 42.9% in patients with NR. The positive rate of glycerol test was 80% in the patients with CR, 68% with PR and 25% with NR. There is statistically significant relationship between the positive rate of glycerol test and the treatment response (p=0.001), but there was no correlation between the positive rate of furosemide test and the treatment response (p=1.000).
CONCLUSION
The significant relationship was found between diuretics treatment and glycerol test. The glycerol test can be used as an indicator for expecting a good treatment response to diuretic therapy.

Keyword

Meniere's disease; Dehydration test; Diuretics

MeSH Terms

Dehydration
Diuretics
Furosemide
Glycerol
Humans
Hydrochlorothiazide
Medical Records
Meniere Disease
Retrospective Studies
Diuretics
Furosemide
Glycerol
Hydrochlorothiazide