Korean J Otolaryngol-Head Neck Surg.  2007 Apr;50(4):319-326.

Expression of S100A4 and S100A2 is Associated with Clinicopathologic Features in Papillary Thyroid Carcinoma

• Jung EJ
• Hah JH
• Jung YH
• Kim SW
• Kwon TK
• Sung MW
• Kim KH

Abstract

BACKGROUND AND OBJECTIVES
S100 calcium-binding proteins are known to play multiple roles in progression and invasion of various carcinomas. In this study, we focused on two kinds of these proteins, S100A4 and S100A2, and investigated their expressions in thyroid neoplasm.
SUBJECTS AND METHOD
We investigated S100A4 and S100A2 expressions in 75 thyroid neoplasms by immunohistochemistry.
RESULTS
S100A4 and S100A2 were not expressed in normal thyroid follicles or follicular carcinomas. Positive relationships were established between S100A4 expression and size (p=.014), invasiveness (p=.029) and T stage (p=.004) of papillary carcinomas. Especially, the S100A4 expression was observed more frequently in the peripheral area (p=.046). But there was no correlation between S100A4 expression with multiple tumor formation and lymph node metastasis. Positive relationships were established between S100A2 expression and size (p=.041), invasiveness (p=.008) and T stage (p<.001) of papillary carcinomas. S100A4 expression was also observed more frequently in the peripheral area (p=.001).
CONCLUSION
These findings suggest that S100A4 and S100A2 contribute to the progression and local invasion of thyroid carcinoma.

Keyword

S100A4; S100A2; Thyroid carcinoma; Immunohistochemistry

MeSH Terms

Calcium-Binding Proteins
Carcinoma, Papillary
Immunohistochemistry
Lymph Nodes
Neoplasm Metastasis
Thyroid Gland*
Thyroid Neoplasms*
Calcium-Binding Proteins