Korean J Pathol.  2001 Jun;35(3):259-262.

Cellular Angiofibroma of the Vulva: A Report of Three Cases

• Choi HJ
• Kim SN
• Kim KR

Abstract

Cellular angiofibroma is a recently described, distinctive soft tissue tumor of the vulvovaginal region which is characterized by small, well-circumscribed tumors with fibroblastic differentiation. We report three cases of cellular angiofibroma of the vulva in middle-aged women. All three patients presented with painless swelling in the labium majora. The age of the three patients ranged from 43 to 56 years old (mean: 48 years old) and the size of the tumor ranged from 2 to 5 cm. The microscopic appearance was characterized by a cellular, well-circumscribed mass composed of uniform, bland, spindle stromal cells, numerous thick-walled, hyalinized vessels, and a scarce component of mature adipocytes. Immunohistochemical stains of the tumor cells show positivity for vimentin but negativity for smooth muscle actin, S-100 protein, desmin, factor VIII-related antigen and epithelial membrane antigen. The tumor should be differentiated from aggressive angiomyxoma and angiomyofibroblastoma because of its different clinicopathologic features, cells of origin and immunohistochemical findings.

Keyword

Angiofibroma; Vulva; Genitalia; Female

MeSH Terms

Actins
Adipocytes
Angiofibroma*
Coloring Agents
Desmin
Female
Fibroblasts
Genitalia
Humans
Hyalin
Middle Aged
Mucin-1
Muscle, Smooth
Myxoma
S100 Proteins
Stromal Cells
Vimentin
von Willebrand Factor
Vulva*
Actins
Coloring Agents
Desmin
Mucin-1
S100 Proteins
Vimentin
von Willebrand Factor